Mechanisms of Enhanced Vascular Reactivtiy in Preeclampsia
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Endothelial Dysfunction Pathophysiology of Hypertension During Preeclampsia Linking Placental Ischemia With
Studies over the past decade have provided a better understanding of the potential mechanisms responsible for the pathogenesis of preeclampsia. The initiating event in preeclampsia has been postulated to be reduced uteroplacental perfusion as a result of abnormal cytotrophoblast invasion of spiral arterioles. Placental ischemia is thought to lead to widespread activation/dysfunction of the mate...
متن کاملMechanisms of enhanced vascular reactivity in preeclampsia.
Preeclamptic women have enhanced blood pressure response to angiotensin II and extensive systemic vascular infiltration of neutrophils. Neutrophils release reactive oxygen species that might activate the RhoA kinase pathway to enhance vascular reactivity. We hypothesized that enhanced vascular reactivity in preeclampsia is attributed to neutrophil-mediated reactive oxygen species activation of ...
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Cardiovascular disease (CVD) remains the leading killer of women in developed nations. One sex-specific risk factor is preeclampsia, a syndrome of hypertension and proteinuria that complicates 5% of pregnancies. Although preeclampsia resolves after delivery, exposed women are at increased long-term risk of premature CVD and mortality. Pre-existing CVD risk factors are associated with increased ...
متن کاملRecent progress toward the understanding of the pathophysiology of hypertension during preeclampsia.
Studies published in Hypertension and other journals over the last few years have provided exciting new insights into potential mechanisms underlying the pathogenesis of hypertension during preeclampsia. Although numerous factors including genetic, immunologic, behavioral, and environmental influences have been implicated in the pathogenesis of preeclampsia, the main focus of this Hypertension ...
متن کاملPathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction.
Studies over the last decade have provided exciting new insights into potential mechanisms underlying the pathogenesis of preeclampsia. The initiating event in preeclampsia is generally regarded to be placental ischemia/hypoxia, which in turn results in the elaboration of a variety of factors from the placenta that generates profound effects on the cardiovascular system. This host of molecules ...
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تاریخ انتشار 2011